Hereditary angioedema: Linking complement regulation to the coagulation system
نویسندگان
چکیده
منابع مشابه
Normal complement C4 values do not exclude hereditary angioedema.
This report describes a patient with hereditary angioedema (HAE) in whom complement C4 values were consistently normal. There was a family history of HAE, for which the patient had previously been screened, but in view of her normal C4 values she was deemed unaffected. However, at 10 years of age she presented with an eight month history of episodes of swelling affecting her hands and recurrent...
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Copyright © 2008 Massachusetts Medical Society. A 19-year-old woman presents to the emergency department with light-headedness, severe abdominal pain, and intractable nausea and vomiting that began 12 hours earlier. The patient reports previous episodes of abdominal pain and swelling of her hands and feet that have been attributed possibly to food allergies, which have recently become more freq...
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As illustrated within the pages of the current issue of the Proceedings, the specialty of allergy–immunology encompasses a diversity of conditions ranging from the quotidian occurrence of the common cough to the rarity of hereditary angioedema. This issue commences with three review articles, all of which were originally presented as problem-based learning cases at the 2013 Eastern Allergy Conf...
متن کاملInteraction between the coagulation and complement system.
The complement system as a main column of innate immunity and the coagulation system as a main column in hemostasis undergo massive activation early after injury. Interactions between the two cascades have often been proposed but the precise molecular pathways of this interplay are still in the dark. To elucidate the mechanisms involved, the effects of various coagulation factors on complement ...
متن کاملThe Pathophysiology of Hereditary Angioedema
Hereditary angioedema (HAE) causes recurrent episodes of angioedema that may be very severe and are frequently associated with significant morbidity and even mortality. Understanding the pathophysiology of this disease is crucial for proper diagnosis and management of these patients. HAE is caused by mutations in the SERPING1 gene that result in decreased plasma levels of functional C1 inhibito...
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ژورنال
عنوان ژورنال: Research and Practice in Thrombosis and Haemostasis
سال: 2018
ISSN: 2475-0379
DOI: 10.1002/rth2.12175